Biocell Guide

Biocell Guide | Biocell Liquid Collagen

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Biocell Collagen Guide

Guide to Biocell Collagen

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Biocell Collagen is the new generation of collagen, altering the way we age and how we perform.
Every product is created with the patented Collagen/HA Matrix Technology to enhance joint and muscle fitness and connective tissue health, combat skin photoaging, restore youthful skin, and support healthy hair, nails, gums and eyes.*

What is Biocell Collagen?

BioCell Collagen is derived from hormone- and antibiotic-free dietary chicken sternal cartilage.  The composition of chicken sternal cartilage is quite similar to that of human cartilage, which is rich in type II collagen, chondroitin sulfate, and hyaluronic acid.  Cartilage is a clean and desirable supply since it is free of diseases and contaminants that can be carried through blood vessels, lymphatics, and nerves.  As a result, extracting only from cartilage reduces the danger of contamination. 

The majority of collagen ingredients on the market come from animal protein in their whole (e.g., cow, pig, and marine).  These materials are commonly branded as Collagen Peptides, Hydrolyzed Collagen, Collagen Hydrolysate, Collagen Type I & III, or Gelatin, and contain more than 90% protein (also a form of hydrolyzed collagen).

BioCell Collagen is a hydrolyzed chicken sternal cartilage extract made up of a naturally occurring matrix that includes collagen type II peptides, chondroitin sulfate, and hyaluronic acid.  BioCell Collagen is GRAS (Generally Recognized As Safe), non-GMO, gluten-free, soy-free, shellfish-free, fish-free, egg-free, milk-free, peanut-free, and sugar-free. 

Collagen Sciences

About Biocell Collagen Products

Collagen and Liquid Biocell - Scientifically Proven to Improve Joint Health and Reverse Aging

What are the Critical Nutritional Elements Found in BioCell Collagen?

BioCell Collagen is a nutritional supplement made from 100% pure hydrolyzed chicken sternal cartilage extract.  BioCell Collagen is made of 60% Hydrolyzed Collagen Type II (measured as Total Protein), 20% Chondroitin Sulfate, and 10% Hyaluronic Acid, according to independent laboratory examination.  The percentages of the previously listed analytes do not add up to 100% since these naturally occurring compounds in chicken cartilage can vary.

BioCell Collagen is a nutritional supplement made from 100% pure hydrolyzed chicken sternal cartilage extract.  BioCell Collagen is made of 60% Hydrolyzed Collagen Type II (measured as Total Protein), 20% Chondroitin Sulfate, and 10% Hyaluronic Acid, according to independent laboratory examination.  The percentages of the previously listed analytes do not add up to 100% since these naturally occurring compounds in chicken cartilage can vary.

Biocell Collagen is the most prevalent protein in the dermis of the skin and joint cartilage.  It keeps your skin strong and resilient, and your joints active and fluid, by providing the structural underpinning for your connective tissues.  Chondroitin sulfate is a naturally occurring component of joint cartilage that provides remarkable shock absorption.  Hyaluronic acid (HA) is a chemical that helps hydrate your skin, lubricates your joints, and binds your cells together with a gel-like material.

It’s also worth noting that the biomolecule synergy present in BioCell’s unique matrix contributes  significantly to its efficacy.  BioCell Collagen has been studied extensively, with seven human clinical trials proving its safety, effectiveness, and bioavailability.

BioCell Collagen is gluten-free, soy-free, shellfish-free, fish-free, egg-free, milk-free, peanut-free, and sugar-free.

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What is the Difference Between BioCell Collagen and Other Collagen Ingredients?

BioCell Collagen is not just an ordinary collagen ingredient. BioCell Collagen is a clinically studied dietary ingredient composed of naturally-occurring hydrolyzed collagen type II peptides, chondroitin sulfate, hyaluronic acid. BioCell’s unique matrix is not a blend of individual ingredients. The synergy of biomolecules found in BioCell’s unique matrix plays a major role in its efficacy. Various studies, including seven human clinical trials, prove the safety, efficacy, bioavailability of BioCell Collagen.

Many collagen supplements on the market lack human clinical studies, do not contain efficacious ingredient quantities, or make false claims. In contrast, BioCell Collagen is backed by clinical studies and an extensive body of research. Multiple human clinical studies have been conducted on BioCell Collagen, demonstrating that 2 grams daily is effective for joint health, while 1 gram daily is effective for skin benefits. These studies provide solid evidence that BioCell Collagen is a unique, healthy aging dietary supplement ingredient that promotes active joints and younger-looking skin. The outcome of these studies was presented in scientific conferences and also published in scientific journals.

Is BioCell Collagen Safe for Human consumption?

Yes, BioCell Collagen has been safely and successfully used by millions of consumers since its introduction in the market in 1998. It was affirmed GRAS (Generally Recognized as Safe) by an independent experts safety panel following rigorous scientific reviews not only in safety and toxicology data, but on manufacturing processes according to food Good Manufacturing Practices (GMP). Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen. BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar.

How does BioCell Collagen Help Skin Age Gracefully?
1. Provides highly bioavailable building blocks to aid in the rebuilding of the dermal matrix.

Collagen, hyaluronic acid (HA), and chondroitin sulfate are all necessary for the skin dermis’s healthy structure and function.

The levels of these components diminish with age, causing the dermal matrix to disorganize or collapse.
BioCell Collagen supplementation has been shown in clinical tests to increase skin beauty from the inside out.
Collagen provides tensile strength to the dermal matrix, which is interwoven with ground compounds like hyaluronic acid.

Increasing the density of dermal fibroblasts, which are responsible for the production of structural components for the dermal network, can also help skin look younger.

2. Improves skin moisture, turgidity, and hyaluronidase inhibition.

Because HA is crucial for keeping water in the skin dermis, maintaining a suitable level of HA is essential for healthy skin structure and turgidity.

Dermal dehydration, skin sagging, and wrinkle development occur as HA and collagen levels decline with age.
BioCell Collagen provides highly accessible HA to help counteract the effects of natural degradation and photoaging.

HA levels in the blood of human individuals who took a daily dose of BioCell Collagen increased 60-fold during the 28-day trial period.

The combined action of HA synthesis and hyaluronidases maintains HA levels.
In response to a variety of normal and pathological stressors, including as aging and inflammation, hyaluronidase destroys HA.

Hyaluronidase has been demonstrated to be inhibited by BioCell Collagen.
As a result, BioCell Collagen can address a key molecular role involved in aging-related dryness while also restoring the skin dermis’ vital structural components.

In a groundbreaking human skin study conducted in 2011, BioCell Technology demonstrated that daily ingestion of BioCell Collagen for 12 weeks resulted in a significant reduction of facial lines and wrinkles, as well as improved hydration and stimulation of collagen biosynthesis, most likely from dermal fibroblasts.

It also resulted in a rise in hemoglobin in face skin tissue, implying improved blood microcirculation in the dermis.
The majority of study participants reported improved skin texture, increased hydration, and less facial scaling.
The findings of the study were reported in the journal Clinical Interventions in Aging (2012).

(http://www.ncbi.nlm.nih.gov/pubmed/22956862)

BioCell Collagen Research Data

Biocell Collagen of a hydrolyzed chicken sternal cartilage preparation

BioCell Collagen has been studied extensively, with seven human clinical trials proving its safety, effectiveness, and bioavailability.   Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen.

Toxicology/Safety Studies

The in vitro, animal and human studies conducted on BioCell Collagen, as well as the extensive historical consumption of BioCell Collagen in dietary supplements since 1998, demonstrate a good safety profile. BioCell Collagen safety data was reviewed by an Expert Panel of toxicology scientists who determined through scientific procedures that the intended uses of BioCell Collagen as a dietary ingredient are Generally Recognized as Safe (GRAS). 

Furthermore, a study was published in Food and Chemical Toxicology in 2007.

BioCell Collagen Human Bioavailability Study

Hyaluronic Acid (HA) is in virtually all tissues of the body. In the joint, HA plays two essential roles. First, it acts as a key structural molecule to form healthy, functional cartilage. Second, HA is a major component of synovial fluid, the lubricant found in our joints that allows smooth and easy movement. In a 28-day bioavailability study in humans showed that ingestion of BioCell Collagen (1500 mg/day) led to a 60 times increase in HA levels at steady state.*

Multiple Human Clinical Trials vs BioCell Collagen Joint Support Studies

In an 80 subject, randomized, double-blind, placebo-controlled trial for joint health, investigators tested the tolerability and efficacy of BioCell Collagen® supplementation. The participants were divided into two groups and administered either 2 g of BioCell Collagen or placebo for 70 days. Compared to placebo, the BioCell group had a significant reduction of joint discomfort on days 35 (p = 0.017) and 70 (p < 0.001). Furthermore, the BioCell group experienced a significant improvement in physical activities compared to the placebo group on days 35 (p = 0.007) and 70 (p < 0.001). BioCell Collagen was well tolerated and found to be effective, thereby improving mobility and quality of life. The peer-reviewed study was published in the Journal of Agriculture and Food Chemistry. (Schauss et al., 2012).

These results were similar to the results of another earlier double-blind placebo-controlled trial tested on sixteen people. (Kalman et al., 2004).* 

Multiple human clinical trials demonstrate the safety and efficacy of BioCell Collagen in promoting joint and skin health.*

Multiple Human Clinical Trials vs BioCell Collagen Joint Support Studies

In an 80 subject, randomized, double-blind, placebo-controlled trial for joint health, investigators tested the tolerability and efficacy of BioCell Collagen® supplementation. The participants were divided into two groups and administered either 2 g of BioCell Collagen or placebo for 70 days. Compared to placebo, the BioCell group had a significant reduction of joint discomfort on days 35 (p = 0.017) and 70 (p < 0.001). Furthermore, the BioCell group experienced a significant improvement in physical activities compared to the placebo group on days 35 (p = 0.007) and 70 (p < 0.001). BioCell Collagen was well tolerated and found to be effective, thereby improving mobility and quality of life. The peer-reviewed study was published in the Journal of Agriculture and Food Chemistry. (Schauss et al., 2012).

These results were similar to the results of another earlier double-blind placebo-controlled trial tested on sixteen people. (Kalman et al., 2004).* 

BioCell Collagen Skin Beauty-from-Within Studies

  1. In a 12-week study, women who took 1000 mg of BioCell Collagen daily had 76% less dryness/scaling, and their fine lines and wrinkles had reduced by 13.2% when compared to baseline levels. Additionally, both collagen levels and microcirculation were significantly improved. The outcome of this study was published in the Clinical Interventions in Aging journal (Schwartz, Park J, 2012)*.

 

  1. In one of the most substantial studies of a skin health supplement, 1000 mg of BioCell Collagen® was found to visibly reduce common signs of skin aging, including lines and wrinkles, within 12 weeks of daily use. The findings reported in this randomized, double-blind, placebo-controlled clinical trial included a measurable improvement in signs of aging in women, represented by increased skin elasticity, reduction of crow’s feet, and improvement in depth and number of fine lines and wrinkles. The full findings of the peer-reviewed study are published in the journal of Alternative Therapies in Health and Medicine. (Schwartz, Hammon KA, 2019)*.

 

 

Modere Liquid Biocell – Before and After

Check out these actual results from subjects who took the daily recommended dose for 12 weeks.†

Liquid biocell before and after
Liquid biocell before after
Liquid BioCell matrix Review Before After

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Biocell Collagen and Liquid Biocell Products

Modere Liquid Biocell Awards

Modere established Collagen Sciences out of the innovative technology behind Liquid BioCell, a groundbreaking nutraceutical for healthy aging, active joints and younger-looking skin.
Backed by many clinical trials, Liquid BioCell is changing the multi-billion dollar anti-aging business and has been recognized with 7 U.S. and international patents and numerous industry awards.

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Work Cited:

Schwartz, S R.  “Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs.”  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426261/

Schauss, A.  “The Effects of Skin Aging Associated with the Use of BioCell Collagen: A Randomized, Double-blind, Placebo-controlled Clinical Trial.”  https://academic.oup.com/cdn/article/3/Supplement_1/nzz031.P06-122-19/5517780

Phipps, K R. “Oral administration of a novel hydrolyzed chicken sternal cartilage extract (BioCell Collagen®) reduces UVB-induced photoaging in mice.”  https://www.sciencedirect.com/science/article/pii/S1756464620300943

Song, Hongdong.  “Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice.”  https://www.mdpi.com/2072-6643/9/11/1209/htm

 

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